烟酰胺

一种医用的维生素B3

科学家发现，只要缺乏维生素B3，就会患上可怕的“糙皮病”。

临床应用

改善新陈代谢，有助于糖尿病治疗

• Crinò, Α., et al. "A Two Year Observational Study of Nicotinamide and Intensive Insulin Therapy in Patients with Recent Onset Type I Diabetes Mellitus." Journal of Pediatric Endocrinology and Metabolism 18.8 (2005): 749-754.

升高肾衰竭患者的HDL

• Cheng, Steven C., et al. "A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients." Clinical Journal of the American Society of Nephrology 3.4 (2008): 1131-1138.

治疗慢性肾病患者的高磷酸盐血症

• Ginsberg, Charles, and Joachim H. Ix. "Nicotinamide and phosphate homeostasis in chronic kidney disease." Current opinion in nephrology and hypertension 25.4 (2016): 285.

保护紫外线的伤害

• Yiasemides, Eleni, et al. "Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans." Carcinogenesis 30.1 (2009): 101-105.

有助于消除皮肤炎症

• Niren, Neil M. "Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review." Cutis 77.1 Suppl (2006): 11-16.

有助于治疗痤疮

• Walocko, Frances M., et al. "The role of nicotinamide in acne treatment." Dermatologic therapy 30.5 (2017): e12481.

降低皮肤癌罹患率

• Chen, Andrew C., et al. "A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention." New England Journal of Medicine 373.17 (2015): 1618-1626.

有助治疗骨关节炎

• Jonas, W. B., C. P. Rapoza, and W. F. Blair. "The effect of niacinamide on osteoarthritis: a pilot study." Inflammation Research 45.7 (1996): 330-334.

抑制黑色素沉淀，促进美白

• Hakozaki, T., et al. "The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer." British Journal of Dermatology 147.1 (2002): 20-31.

辅助治疗黄褐斑

• Navarrete-Solís, Josefina, et al. "A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma." Dermatology research and practice 2011 (2011).

有助于治疗牛皮癣

• Zackheim, Herschel S. "Topical 6-aminonicotinamide plus oral niacinamide therapy for psoriasis." Archives of dermatology 114.11 (1978): 1632-1638.

你知道吗？

一般的烟酸具有促进血液循环的作用，所以当皮肤表面附近的血管扩张时，可能会引起刺痛感和潮红，或出现胃部不适的感觉。这系列的医疗反应都是无害的，不必过度惊慌。然而，烟酰胺的结构有别，所以不会让您潮红。

Q&A

过量的烟酰胺有副作用吗?

研究显示，每天服用超过3000毫克的烟酰胺可能损伤肝功能，所以最好依据治疗师的指示，按着各人需要来服用。

• Knip, M1, et al. "Safety of high-dose nicotinamide: a review." Diabetologia 43.11 (2000): 1337-1345.