双歧杆菌

诺贝尔奖得主的推荐

广泛存在于人和动物的消化道、阴道和口腔等生境中的重要益生菌。

临床应用

改善幽门螺旋杆菌导致的症状

• Lau, Christine SM, Amanda Ward, and Ronald S. Chamberlain. "Probiotics improve the efficacy of standard triple therapy in the eradication of Helicobacter pylori: a meta-analysis." Infection and drug resistance 9 (2016): 275.

有效预防旅行者腹泻(traveler’s diarrhea)

• McFarland, Lynne V. "Meta-analysis of probiotics for the prevention of traveler's diarrhea." Travel medicine and infectious disease 5.2 (2007): 97-105.

防治抗生素相关腹泻(antibiotic-associated diarrhea)

• Hempel, Susanne, et al. "Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis." Jama 307.18 (2012): 1959-1969.

改善肥胖及相关代谢疾病

• Dahiya, Dinesh K., et al. "Gut microbiota modulation and its relationship with obesity using prebiotic fibers and probiotics: a review." Frontiers in microbiology 8 (2017): 563.

有助于降低血压

• Dong, Jia-Yi, et al. "Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials." British journal of nutrition 110.7 (2013): 1188-1194.

有助于改善大肠激躁症IBS

• Guyonnet, D., et al. "Effect of a fermented milk containing Bifidobacterium animalis DN‐173 010 on the health‐related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double‐blind, controlled trial." Alimentary pharmacology & therapeutics 26.3 (2007): 475-486.

调节肠道功能

• Pitkala, K. H., et al. "Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial." Journal of Nutrition Health and Aging 11.4 (2007): 305.

增强免疫能力

• Chiang, Bor-Luen, et al. "Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses." European journal of clinical nutrition 54.11 (2000): 849-855.

临床证实改善腹胀

• Ringel, Yehuda, et al. "Clinical trial: probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders-a double-blind study." Journal of clinical gastroenterology 45.6 (2011): 518.

防止湿疹的恶化发展

• Kim, Ji Yeun, et al. "Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trial." Pediatric Allergy and Immunology 21.2p2 (2010): e386-e393.

对抗白色念珠菌

• TOMODA, Tsunesuke, Yasuo NAKANO, and Takashi KAGEYAMA. "Intestinal Candida overgrowth and Candida infection in patients with leukemia: effect of Bifidobacterium administration." Bifidobacteria and Microflora 7.2 (1988): 71-74.

改善忧郁症状

• Pinto-Sanchez, Maria Ines, et al. "Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome." Gastroenterology 153.2 (2017): 448-459.

改善溃疡性结肠炎(ulcerative colitis)

• Ishikawa, Hideki, et al. "Beneficial effects of probiotic bifidobacterium and galacto-oligosaccharide in patients with ulcerative colitis: a randomized controlled study." Digestion 84.2 (2011): 128-133.

你知道吗？

双歧杆菌对人体健康意义重大，甚至被成为人体健康的晴雨表。到老年时期，体内的双歧杆菌会大幅减少。

1899年，法国巴斯德研究所的儿科医生亨利(Henry Tissier)从母乳喂养的健康婴儿粪便中首次分离出双歧杆菌，并发现补充这种双歧杆菌能治疗肠道感染方面的疾病。

随后，诺贝尔奖得主梅契尼科夫寻访东欧保加利亚地区的长寿村，发现当地的人瑞个个爱吃酸奶，因此提出长期服用益生菌有助长寿的学说。

Q&A

双歧杆菌吃多了会导致脑雾吗？

研究显示，小肠细菌过度增生(Small Intestinal Bacterial Overgrowth, SIBO)患者的脑雾现象可能和补充益生菌有关。但如果您不是SIBO患者，则不必过度担心相关问题。

• Rao, Satish SC, et al. "Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis." Clinical and translational gastroenterology 9.6 (2018): 162.